Economics Department Working Paper Series, TU Braunschweig nat. To develop neutralizing anti-SARS-CoV-2 antibodies, antibody gene libraries from convalescent COVID-19 … Unsere Abteilungen; Unsere Lehrveranstaltungen; Braunschweiger Zentrum für Systembiologie (BRICS) Forschungsförderung; Unsere Kooperationspartner ; Stellenausschreibung; Bildnachweis: Dr. Hilger Jagau/Alle Rechte bei der TU Braunschweig Biozentrum Spielmannstraße 7 38106 Braunschweig . Data integration with SYSTOMONAS combines two different principle concepts, the data warehouse concept (14) and dynamic web services via SOAP. Broad data integration is realized using SOAP interfaces for the well established databases BRENDA, KEGG and PRODORIC. This makes the Technische Universität the most established and traditional university in Germany. 2Zentrum für Pharmaverfahrenstechnik (PVZ), Technische Universität Braunschweig, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany. Our initial focus was on metabolomics. Angestellt, Werkstudentin am Institut für Marketing, Technische Universität Braunschweig. Moreover, 11 exemplary protein spots from one proteome experiment were entered. Welcome to the Institute of Applied Biosciences (IAB) The Institute of Applied Biosciences was founded in 2005 and consists of seven different departments. For P.aeruginosa PAO1 1509 unique proteins were annotated in SYSTOMONAS as enzymes. We have chosen the Gram negative proteobacterium Pseudomonas aeruginosa. Working Paper Series, Institut für Finanzwirtschaft, TU Braunschweig For this purpose, a major portion of the data of SYSTOMONAS, such as KEGG compounds, reactions or PRODORIC transcription factor—gene interactions is locally stored. Intercultural Communication. Dear students and all interested parties, we are re-designing our website and want to include you in the process. Institut für Mikrobiologie, Molekulare Infektionsbiologie; null, Germany; Position. However, all current information coming from genomics, transcriptomics and proteomics (13) is also stored in our database as data warehouse (14) or dynamically accessible via web services using SOAP interfaces (15), a platform-independent data transfer protocol (see section ‘Database Techniques’). It also refers to genome annotation web sites of other Pseudomonas genome projects for the most up-to-date information. Fähigkeiten und Kenntnisse. International business. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Braunschweiger Forscher ernten Kartoffeln für die Wissenschaft. Combining knowledge from multiple disciplines and data resources will drive our understanding of cellular processes and lead to the prediction of the cellular behaviour in its entirety. Besides our own experimental metabolome, proteome and transcriptome data, various additional predictions of cellular processes, such as gene-regulatory networks were stored. Principal institution: Department of Life Sciences (FLW), TU Braunschweig. With 20,000 students and 3,700 employees, we are the largest technical university in Northern Germany. Our long term goal is the development of a dynamic model simulating the behaviour of P.aeruginosa during infection. The E-value of BLAST and the identity calculated by stretcher can be retrieved by activating the two multiple alignment tools. We offer teaching, research and transfer with excellent facilities and a personal atmosphere at the same time. Box: 38092 Braunschweig GERMANY. 0313398A), BMBF for the Bioinformatics Competence Center Intergenomics (Grant No. We adapted this tool to SYSTOMONAS by limiting the analysis on Pseudomonas species. All known metabolic reactions are depicted here for the ‘Urea cycle and metabolism of amino groups’ pathway. Technische Universität Braunschweig Hans-Sommer-Straße 4 38106 Braunschweig Veröffentlichungen und Institutsberichte Prof. Dr.-Ing. Institut für Mikrobiologie, TU Braunschweig Germany . Technische Universität Braunschweig Institut für Füge- und Schweißtechnik. Institut für Klinische Radiologie, Klinikum der Universität München, Munich, Germany München Vor 3 Tagen Gehören Sie zu den ersten 25 Bewerbern. E-mail address: h.waetzig@tu‐ Technische Universität Braunschweig, Institut für Pharmazeutische Chemie, Braunschweig, Germany. Universität Regensburg, Institut für Biochemie, Genetik und Mikrobiologie … Klaus Brehm Institut für Hygiene und Mikrobiologie. Comparing a Pseudomonas protein of interest with other well-characterized proteins may deliver useful insights into the evolution, distribution and species specific function. Technische Universität Braunschweig. Rectangles depict metabolic reactions, ellipses represent metabolites whose names are abbreviated with an asterisk * when the length exceeds 10 letters. Institut für Organische Chemie. Currently, SYSTOMONAS contains 10 034 proteins identified as enzymes, 195 transcription factor–gene relations, 14 250 measuring points of three independent metabolome experiments. The Technische Universität Braunschweig is the academic centre of Braunschweig in the centre of Europe's most active research region. A more dynamic and flexible tool for the visualization of multiple alignments is provided by Jalview (21), which is also accessible from SYSTOMONAS. We provide SBML (27) formatted files for downloading our metabolic and gene-regulatory networks along with a database copy at the SYSTOMONAS website. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Contact. Despite this importance, the molecular mechanisms mediating this process are only poorly understood in biological systems. The corresponding annotation process is described in the following sections. All newly detected EC numbers by metaSHARK are also indicated as ‘predicted’ in SYSTOMONAS. Institut für Fahrzeugtechnik TU Braunschweig Aufsätze in Zeitschriften Nr. Most enzyme information was provided by KEGG. The web services via SOAP, which are used on the websites of SYSTOMONAS, are listed in Table 2. Biozentrum Spielmannstraße 7 38106 Braunschweig, Telefon +49-(0)531-391-5800 Telefax +49-(0)531-391-5854, Braunschweiger Zentrum für Systembiologie (BRICS) Rebenring 56 38106 Braunschweig, Stellen der TU Braunschweig Jobbörse des Career Service Merchandising Sponsoring- & Spendenleistungen Drittmittelgeförderte Forschungsprojekte, Semestertermine Lehrveranstaltungen Studiengänge von A-Z Informationen für Erstsemester TUCard, Status GITZ-Dienste Handbuch für TYPO3 (Intern) Corporate Design-Toolbox (Intern) Glossar (DE-EN) Meine Daten ändern Hochschulöffentliche Bekanntmachungen, Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig Postfach: 38092 Braunschweig Telefon: +49 (0) 531 391-0. Many thanks go to Mathias Krull and Barbara Schulz, who proof-read this paper. In particular, the step of plasma membrane merger and the contributing proteins and physicochemical factors remain mostly unknown. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. First, the external databases KEGG (9), PGDv2 (16), ENZYME (17), BioCyc (5) provide EC numbers for the proteins. To reconstruct metabolic networks, we transferred known EC numbers of each Pseudomonas protein to its homologous partners. Further enzymes were annotated by comparative genomics (column ‘Predicted’), which were missing in the databases mentioned afore. Harnessing lymphoma epigenetics to improve therapies (article not eligible for CME credit). Besides the medically relevant P.aeruginosa the genera Pseudomonas contains various important plant pathogens and biotechnologically as well as ecologically interesting species. 38106 Braunschweig Professorin Dr. Christine Falk: Medizinische Hochschule Hannover (MHH) Institut für Transplantationsimmunologie Carl-Neuberg-Straße 1 30625 Hannover Professorin Dr. Nicole Frankenberg-Dinkel: Technische Universität Kaiserslautern Fachbereich Biologie Fachgebiet Mikrobiologie Paul-Ehrlich-Straße 23 67663 Kaiserslautern Professor Dr.-Ing. The homologous protein pairs can be obtained from the SYSTOMONAS protein table and visualized as multiple alignments, which are produced by MUSCLE [MUltiple Sequence Comparison by Log-Expectation (20)]. If the levels of specific metabolites differ significantly between different conditions, the measured values are found distinct to a fictive diagonal line. 1Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany. The metabolite name for every data point is shown as tooltip while moving the mouse over the point (e.g. Street: Langer Kamp 8: Zip-Code: 38106: City: Braunschweig: Website: Long Description: The institute of joining and welding of the Technical University of Braunschweig has approximately 60 employees, 35 thereof being scientific staff. Upon registration you will receive an e-mail for confirmation. For a start, we included our own experimental data obtained for the P.aeruginosa strain PAO1 measured under different growth conditions. Tel. Box: 38092 Braunschweig GERMANY. … Teaching Winter Semester 2020/2021; CS department TU Braunschweig Technische Universität Braunschweig Fakultäten Fakultät 2: Fakultät für Lebenswissenschaften Institute der Fachrichtung Biologie Institut für Mikrobiologie - - - 1. Zur anonymisierten Webanalyse nutzt die TU Braunschweig die Software Matomo. Technische Universität Braunschweig, Helmholtz-Zentrum für Infektionsforschung. This organism is a versatile soil bacterium and an important opportunistic pathogen causing persistent infection in immunocompromised patients (12). Hartmut Fricke: Technische … 031U110A/031U210A) and the Volkswagen Foundation. The 1509 annotated enzymes were retrieved from KEGG (1003), PGDv2 (1017), BioCyc (493), ENZYME (393) and from our own annotation (241). Mit 'OK' verlassen Sie die Seiten der Universität Würzburg und werden zu Twitter weitergeleitet. Intern BMW Manufacturing Co., LLC März 2020 – Sept. 2020 7 Monate. Technische Universität Braunschweig, Braunschweig, Germany We have chosen the open source object-relational database management system PostgreSQL 8.0.3 (Author Webpage) for our database. Graphical maps of corresponding gene regions can be retrieved via a hyperlink to the BRENDA Genome Explorer, a tool within the BRENDA package (8). Herzlich Willkommen auf der offiziellen Facebook-Seite der TU Clausthal! Ovarian cancer risk score predicts chemo-response and outcome in epithelial ovarian carcinoma patients. 1 Türk-Alman Üniversitesi, Fen Fakültesi, Istanbul, Turkey Technische Universität Braunschweig, Institut für Mikrobiologie, Braunschweig, Germany Cell-to-cell fusion is crucial for the development and propagation of most eukaryotic organisms. Mikrobiologie; So finden Sie uns; Startseite; Home; Impressum; Datenschutz; Barrierefreiheit; Sitemap; suchen. 28.09.2020 Schwarzen Flecken in der Kartoffel auf der Spur. BRENDA supports kinetic and disease information. Mareike Dressler. Technische Universität Braunschweig, Institut für Pharmazeutische Chemie, Beethovenstraße 55, 38106 Braunschweig, Germany Fax: +49‐531‐391‐2799===Search for more papers by this author Ferit Küçükay Tagungsbeiträge . Research; Relationships; 1 August 2019 - 31 July 2020. 2 Technische Universität Braunschweig, Institut für Mikrobiologie, Braunschweig, Germany Helmholtz Centre for Infection Research, Braunschweig, Germany External web services implemented on the SYSTOMONAS (S.) websites via SOAP. Logg Dich jetzt ein, um das ganze Profil zu sehen. The authors are much obliged to Frank Klawonn for advising in the statistical part of metabolomics comparison. Institut für Mikrobiologie. Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig. There are various tools for metabolic network reconstruction [e.g. 2. Universität Zürich Institut für Medizinische Mikrobiologie Über uns Personen/People Team Forschung Research Group Seeger Markus Seeger Seitenfunktionen Druckansicht Here we focus on data integration for the biotechnologically and medically relevant group of bacteria, the pseudomonads. Arbeitspapiere des Instituts für Marketing, TU Braunschweig Gerhard Bringmann. Search for more papers by this author. SYSTOMONAS architecture: combining the data warehouse concept and web services to provide a quick and dynamically updated data integration. (4)Zentrum für Biochemie, Medizinische Fakultät, Universität zu Köln, Joseph-Stelzmann-Strasse 52, Köln 50931, Germany Die Daten dienen dazu, das Webangebot zu optimieren.Weitere Informationen finden Sie in unserer Datenschutzerklärung. The database structure of SYSTOMONAS is suitable for the simple storage of various types of experimental data. : ++49 931-31-46168 Search for more papers by this author. P. O. Major external sources of SYSTOMONAS are KEGG [Kyoto Encyclopedia of Genes and Genomes (9)], Pseudomonas Genome Database v2 [PGDv2 (16)], PRODORIC [PROcaryotIC Database Of gene-Regulation (4)], and BRENDA (8). This database is accessed with the scripting language PHP (Author Webpage), which also allows the dynamic generation of the web interface. Besides other research groups and our own experimental results further data are retrieved from major general data resources. We need your help to improve our website! As an extra feature, the metabolomics data obtained for one specific growth condition can be plotted against another dataset using gnuplot (Author Webpage). Ferit Küçükay Tagungsbeiträge . This work was funded by the German Bundesministerium für Bildung und Forschung (BMBF) for the National Genome Research Network (NGFN2-EP, grant no. University of California, Janin Heuer. Search for more papers by this author. The main data sources of SYSTOMONAS are stored and matched in an intermediate data container ‘metabold’, which supplies data to SYSTOMONAS (Figure 3). COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, a novel betacoronavirus discovered in December 2019 and closely related to the SARS coronavirus (CoV). Telefon (Sekretariat) +49 40 42878-32 08 | Fax +49 40 42878-23 15 | E-Mail Herzlich willkommen auf der offiziellen Facebook-Seite der TU Braunschweig! Both viruses use the human ACE2 receptor for cell entry, recognizing it with the Receptor Binding Domain (RBD) of the S1 subunit of the viral spike (S) protein. The S2 domain mediates viral fusion with the host … Sehen Sie, wen Institut für Klinische Radiologie, Klinikum der Universität München, Munich, Germany für diese Position eingestellt hat. Several databases provide web services via SOAP, such as the major sequence databases (23–25). None declared. Institut für Fahrzeugtechnik, Technische Universität Braunschweig Jan. 2019 –Heute 2 Jahre. Kinetic data and corresponding references, Transcription factors, DNA binding sites, and corresponding references, Experimental conditions for expression profile experiments, Expression profiles experiments and corresponding references. Your comment will be reviewed and published at the journal's discretion. Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig. Whenever a webpage with these web services is accessed, the data is retrieved from the actual external database and amends the locally stored data of SYSTOMONAS. EC numbers newly identified by our method are declared as ‘predicted’. With this database we would like to encourage the Pseudomonas community to elucidate cellular processes of interest using an integrated systems biology strategy. The enzyme designation of proteins was determined in three steps. José V. Ramos. Several tools for the analysis of stored data and for the visualization of the corresponding results are provided, enabling a quick understanding of metabolic pathways, genomic arrangements or promoter structures of interest. Institut für Mikrobiologie, Technische Universität Braunschweig Spielmannstraße 7, 38106 Braunschweig, Germany. Institut für Biophysikalische Chemie. Deutschland. ASAM Technical Seminar Oct 08 - 09, 2020. Metabolites measured from samples of exponentially growing cells under aerobic conditions are plotted along the x-axis against metabolites from samples of resting cells along the y-axis. Our core research fields are mobility, infections and therapeutics, metrology and the city of the future. Institut für Fahrzeugtechnik TU Braunschweig Aufsätze in Zeitschriften Nr. Therefore, we searched for all deduced proteins of the SYSTOMONAS database for orthologous proteins in other Pseudomonas species to obtain orthologous protein clusters. Medizinische Hochschule Hannover. … We are planning to make up for the Technical Seminar which had to be canceled in March due to the coronavirus outbreak. Currently, the data of SYSTOMONAS along with its visualization tools and web services can be accessed freely via a web-based user interface (Author Webpage).